This Week In Startups is made possible by: Northwest Registered Agent - https://www.northwestregisteredagent.com/twistdomain NetSuite - https://www.netsuite.ai/twist Vanta - http://www.vanta.com/twist Today’s show: An Anthropic researcher quit this week, saying both leading labs are gambling with everyone's lives. His coworker chimed in and predicts there is a greater than 10% chance that AI will end humanity IN THE NEXT 10 YEARS. Jason and Lon take it to Yohei Nakajima of Untapped Capital, Ben Lerer of Lerer Hippeau, and Rebecca Lynn of Canvas Prime, who cannot decide whether it is the greatest PR strategy in history or some kind of mass psychosis. Learn why Jason says founders should never hand a frontier lab their proprietary data, whether or not they're offered free credits. PLUS, who really solved Navier-Stokes, and what does the OpenAI–Buckmaster fight mean for anyone doing real work inside ChatGPT or Claude? Guests: Yohei Nakajima on X: https://x.com/yoheinakajima Untapped Capital: https://untapped.vc/ Ben Lerer on X: https://x.com/BenjLerer Lerer Hippeau: https://www.lererhippeau.com/ Rebecca Lynn on X: https://x.com/VCRebecca Canvas Prime: https://www.canvas.vc/ Relevant Links: Jacob Coxon quits Anthropic - "gambling with our lives" https://techcrunch.com/2026/09/09/gambling-with-our-lives-anthropic-researcher-quits-warns-against-self-improving-ai/ Evan Hubinger, Anthropic's Alignment Science lead, on X: 10% odds within a decade — https://x.com/EvanHub/status/2097497037956891126 Future of Life Institute — the 2015 Puerto Rico AI safety conference Jason asks Lon to pull up https://futureoflife.org/ Meta debuts Muse (Axios) —https://www.axios.com/2026/09/08/meta-debuts-muse-personal-ai-agent Harmonic — https://harmonic.ai/ China blocks Meta's Manus acquisition (CNBC)https://www.cnbc.com/2026/04/27/meta-manus-china-blocks-acquisition-ai-startup.html OpenAI fought dirty— https://techcrunch.com/2026/09/08/openai-fought-dirty-on-career-making-math-problem-says-nyu-mathematician/ Savvy Wealth — https://www.wealthmanagement.com/ria-news/savvy-wealth-raises-100m-valuation-hits-600m Augmodo — https://www.augmodo.com/ E2B — https://e2b.dev/ Daptic — https://www.daptic.com/ Timestamps: 0:00 Jacob Coxon quits Anthropic: "crunch time" and "endgame" 4:10 Evan Hubinger: 10% odds AI kills all humans in a decade 10:39 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.com/twistdomain 14:16 Jobs, the wealth divide, and which industries get wiped out first 19:24 NetSuite - For the first time ever, you can try NetSuite Next for free. If your revenues are at least in the seven figures, go to https://NetSuite.ai/TWIST 20:26 Savvy Wealth's $100M round 28:21 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 31:22 Meta ships Muse 32:13 Can Meta be trusted 34:46 Threads Metrics 48:44 Robinhood's free-share referral 50:33 NYU's Tristan Buckmaster accuses OpenAI of fighting dirty on Navier-Stokes 57:00 Jason: "It's a trap" 58:20 Harvey goes open-weight, Go.AI on-prem, Covenant Labs 1:11:39 High performing portfolio companies Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com